Taxonomy of actinomycetes capable of hydroxylation of ML-236B (compactin).
نویسندگان
چکیده
Three actinomycetes having capability of 3 beta-hydroxylation of ML-236B were isolated from soil samples collected in Australia. Strain SANK 62781 was identified as Nocardia autotrophica. Strain SANK 62881 and strain SANK 62981 were identified as new subspecies of N. autotrophica for which the name N. autotrophica subsp. canberrica and N. autotrophica subsp. amethystina are proposed, respectively. The type strains of N. autotrophica subsp. canberrica and N. autotrophica subsp. amethystina are ATCC 35203 and ATCC 35204.
منابع مشابه
Formation of dihydroxy derivative of ML-236B from ML-236B (compactin) by lipid peroxidation.
monooxygenase system in Strepiomyces carbophilus that hydroxylates sodium ML-236B-carboxylate to pravastatin6). Dihydroxy derivative of ML-236B is also obtained in case of S. carbophilus. At first, we determined whether the formation of dihydroxy derivative of ML-236Bdepends upon cytochrome P-450sca monooxygenase or not. According to that paper, S. carbophilus was cultured and cytochrome P-450s...
متن کاملGrowth inhibition of yeast by compactin (ML-236B) analogues.
Numbers in the parentheses represent relative activity to inhibit rat liver HMG-CoAreductase. The present communication deals with sensitivity of the growth of yeast strains to compactin. Of approximately 300 strains tested, 4 strains, Rhodotorula glutinis H3-9-1, Sporobolomyces salmonicolor WF 188, Aessosporon salmonicolor IFO 1845 and Citeromyces matritensis IFO 0954, were found to be sensiti...
متن کاملInduction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase.
The two compounds compactin and ML-236B are identical fungal metabolites isolated from strains of Penicilliunz brevicompactum and Penicillium citrinum, respectively. ML-236B has been shown to be a potent competitive inhibitor of rat liver microsomal 3-hydroxy-3-methylgluiaryl coenzyme A reductase (HMG-CoA reductase), the rate-controlling enzyme in cholesterol biosynthesis (Endo, A., Kuroda, M.,...
متن کاملThe synthesis of compactin (ML-236B) and monacolin K in fungi.
Compactin (ML-236B) and monacolin K (mevinolin) are specific inhibitors of 3-hydroxy3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in cholesterol biosynthetic pathway1~7). ML-236B was isolated from Penicillium citrinuml) and Penicillium brevicompactum2), and monacolin K from Monascus ruber4) and Aspergillus terreus6). In the present study, approximately 4,000 newly is...
متن کاملX-ray crystal structure of the tert-octylamine salt (RMS-431) of pravastatin.
In the course of studies to detect specific inhibitors of cholesterol synthesis from microbial products, several compounds were isolated from the culture broth of Penicillium dtrinum.^ One compound, sodium (+)-(3i?,5i?)-3,5-dihydroxy7-[(l S,2S,6S,8£,8ai?)-6-hydroxy-2-methyl8 [(£)2-methylbutyryloxy] 1 , 2, 6, 7, 8, 8a-hexahydro1naphthyl]heptanoate (CS-514) (la, pravastatin sodium) found as a min...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 36 9 شماره
صفحات -
تاریخ انتشار 1983